Ketamine 'should be upgraded to Class B'

[ezza]

altho theyre fun fuck nos balloons man ive seen people turn blue in the face and fall over and STILL try to puff on those things

dat oxygen starvation

yeah i held my breath for a minute and then inhaled one and passed the fuck out

pretty sketchy thinking back on it

[alphacat]

your body not having the tools to break down synthetic material wtf are you talking about?

When administered orally, it undergoes first-pass metabolism, where it is biotransformed in the liver by CYP3A4 (major), CYP2B6 (minor), and CYP2C9 (minor) isoenzymes into norketamine (through N-demethylation) and finally dehydronorketamine. Intermediate in the biotransformation of norketamine into dehydronorketamine is the hydroxylation of norketamine into 5-hydroxynorketamine by CYP2B6 and CYP2A6. Dehydronorketamine, followed by norketamine, is the most prevalent metabolite detected in urine.

This thread explains/speculates on the mechanism for the bladder damage. http://www.bluelight.ru/vb/threads/3114 ... e-cystitis

In my opinion if bud is a class B then so should K, although dr nutt made a good point he said that if it goes class B then vets won't be able to use it in the field and the poor animals will suffer so i dunno.

Let me rephrase: your body can actually "pass" pretty much any toxin that doesn't out and out kill you, but the amount of intense fucking effort required by the renal system (remember that bladder stuff?) means it's very, very taxing on your body.

From: http://www.ncbi.nlm.nih.gov/m/pubmed/1466470/

Ketamine undergoes extensive hepatic metabolism...

This means that the series of conversions your body makes is long and involved... Unlike food and organic metabolites.

And cannabis is B because of straight up disinformation. Srsly.

[test_recordings]

Actually, pretty much all drug classification is arbitrary. The AMCD's recommendation is probably one of the few that actually uses sound logic.

[m8son666]

Let me rephrase: your body can actually "pass" pretty much any toxin that doesn't out and out kill you, but the amount of intense fucking effort required by the renal system (remember that bladder stuff?) means it's very, very taxing on your body.


From: http://www.ncbi.nlm.nih.gov/m/pubmed/1466470/

Ketamine undergoes extensive hepatic metabolism...

Agent, this is only true if your body has the chemical "tools" to break it down. In the case of synthetics, your body does not.

Yeah i know about hepatic metabolism lol i am doing a masters degree in pharmacology, if you read what you said before you can see how i wasn't sure what you were saying. Also if the effects on the bladder are due to the fact that 'in-organic', as you would say, compounds require intense effort on behalf of the renal system why are other synthetics not causing the same problems?

[hugh]

tolerance isnt the point im making tho

surely the damage comes from constant use of your body always trying to process a toxin

if you do it and then over the next 5 days your body flushes it out your system surely your good to go again

Many many toxins that are a product of catabolism are actually sequestered in your cells for the rest of your life. They are effectively "quarantined", either indefinitely, or for a long time before eventual biodegradation, because your body doesn't know how to deal with them. It can actually be a cause of cell lysis in extreme circumstances.

[m8son666]

#science

[ezza]

the reason there upping the class is cus of health reasons

but the fact it will be class b is gonna stop no one

[bennyfroobs]

Yeah i know about hepatic metabolism lol i am doing a masters degree in pharmacology

lmao

#base

i wasnt expecting that

[ezza]

ennit i thought mason was a proper fucking idiot

in a nice way doe

props for being a dork u 4 eyed tnuc go read a book lol were u going tonigt? libary?

[m8son666]

loool i am a proper fucking idiot but luckily they give degrees to idiots now lol

anyway its a chemistry w/pharmacology degree and i am not doing the masters yet so what i said aint completley true lol

[m8son666]

props for being a dork u 4 eyed tnuc go read a book lol were u going tonigt? libary?

oi m8 go an have fun u jock prick go play some sports or whateva u jocks do play with jockstraps n shit yh

[ezza]

lol thats the american insults lol wat u doin

in english u would be like well at least im not laying bricks u plumber twat

[m8son666]

alrit u binman fuk go an suk the queens nob u poof

[ezza]

lol big ups the derail

back on subject, anyone ever put k in their eyes? met this dude who said if you mix it with a bit of water and wack it in your eyes its alot more intense but its stings n u cant see for a bit

also, it blocks my nose after a while so i physically cant take anymore... and your not really spose to swallow it ennit. what to do

[m8son666]

put it up ur bum or inject it into ur muscvles

[jrkhnds]

any mucous membrane should work. eyes are fucking stupid. supersmall surface that actually interacts with substances/water etc. you'll need more K than nasal and it'll take longer to kick in. bum & bell-end offer mucous membranes. glans will most likely just lead to local anaesthesia though, similar to coke. women are a bit luckier in that regard.

you culd just rub it on your gums and the inside of your cheeks.

[test_recordings]

I remember getting the drip down the back of the throat as the bends came on, ran to the kitchen to take a swig of milk to stop the acid feeling... and it was fucking off

[m8son666]

yh lol put ket up ur bellend

[jrkhnds]

[Genevieve]

On some sort of list for sex offenders?